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Q. No.The first clinical gene therapy was given in 1990 to a 4-year old girl with:
1. X-linked severe combined immunodeficiency
2. Adenosine deaminase (ADA) deficiency
3. Purine nucleoside phosphorylase deficiency
4. Omenn syndrome
Subtopic: Gene Therapy |
98%
From NCERT
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Consider the given two statements:
| Statement I: | In some children, ADA deficiency can be cured by bone marrow transplantation; in others, it can be treated by enzyme replacement therapy. |
| Statement II: | Both these approaches are completely curative. |
| 1. | Statement I is correct; Statement II is correct |
| 2. | Statement I is correct; Statement II is incorrect |
| 3. | Statement I is incorrect; Statement II is correct |
| 4. | Statement I is incorrect; Statement II is incorrect |
Subtopic: Gene Therapy |
86%
From NCERT
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Consider the given two statements:
| Assertion (A): | Introduction of functional ADA cDNA (using a retroviral vector) into lymphocytes from patient’s blood is not a permanent cure in ADA deficiency. |
| Reason (R): | Lymphocytes are absent from the blood of ADA deficiency patients. |
| 1. | (A) is True, (R) is True and (R) correctly explains (A). |
| 2. | (A) is True, (R) is True but (R) does not correctly explain (A). |
| 3. | (A) is True but (R) is False. |
| 4. | (A) is False, (R) is False. |
Subtopic: Gene Therapy |
71%
From NCERT
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Consider the given tow statements:
| Statement I: | The biological significance of manipulation of living organisms by humans is important. |
| Statement II: | Genetic modification of organisms can have unpredictable results when such organisms are introduced into the ecosystem. |
| 1. | Statement I is correct; Statement II is correct |
| 2. | Statement I is correct; Statement II is incorrect |
| 3. | Statement I is incorrect; Statement II is correct |
| 4. | Statement I is incorrect; Statement II is incorrect |
Subtopic: Ethical Issues |
79%
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If successful and found to be reliable, what GM animals could replace the use of monkeys to test the safety of batches of the oral polio vaccine?
1. Rats
2. Rabbits
3. Mice
4. Pigs
1. Rats
2. Rabbits
3. Mice
4. Pigs
Subtopic: Transgenic Microbes & Animals |
89%
From NCERT
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Insulin isolated from other animals and used in humans:
1. Only I is correct
2. Only II is correct
3. Both I and II are correct
4. Both I and II are incorrect
| I: | will be just as effective as that secreted by the human body itself. |
| II: | would not elicit an immune response in the human body. |
1. Only I is correct
2. Only II is correct
3. Both I and II are correct
4. Both I and II are incorrect
Subtopic: Med Applications & Humulin |
59%
From NCERT
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Eli Lilly prepared two DNA sequences corresponding to A and B chains of human insulin and introduced them in:
| 1. | plasmids of E. coli to produce insulin chains. |
| 2. | pBR322 plasmids to produce insulin chains. |
| 3. | pUC101 plasmids to produce insulin chains. |
| 4. | Ti plasmids of Agrobacterium to produce insulin chains. |
Subtopic: Med Applications & Humulin |
91%
From NCERT
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Which peptide, present in the pro-insulin, is absent from the final structure of insulin?
1. The A peptide
2. The B peptide
3. The C peptide
4. The A and C peptides
1. The A peptide
2. The B peptide
3. The C peptide
4. The A and C peptides
Subtopic: Med Applications & Humulin |
97%
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The first recombinant therapeutic product approved for human use was:
1. Flavr Savr
2. EPO
3. Human Growth Hormone
4. Human Insulin
1. Flavr Savr
2. EPO
3. Human Growth Hormone
4. Human Insulin
Subtopic: Med Applications & Humulin |
95%
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What was used to introduce Meloidogyne incognita-specific genes into the tobacco plant for silencing the specific mRNA of the nematode?
| 1. | Gene gun | 2. | Microinjection |
| 3. | Agrobacterium | 4. | Liposome |
Subtopic: Interference RNA Tech |
91%
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