Molecular basis of organ differentiation depends on the modulation in transcription by:

(1) RNA polymerase

(2) ribosome

(3) transcription factor

(4) anticodon

The length of DNA molecule greatly exceeds the dimensions of the nucleus in eukaryotic cells. How is this DNA accommodated?

1. Deletion of non essential genes

2. Super-coiling in nucleosomes

3. DNAse digestion

4. Through elimination of repetitive DNA

During transcription RNA polymerase holoenzyme binds to a gene promoter and assumes a saddle-like structure. What is it’s DNA-binding sequence?

(1) TTAA

(2) AATT

(3) CACC

(4) TATA

Differentiation of organs and tissues in a developing organism, is associated with:

1. developmental mutations

2. differential expression of genes

3. lethal mutations

4. deletion of gens

The Okazaki fragments in DNA chain growth:

(1) result in transcription

(2) polymerize in the 3’-to-5’ direction and forms replication fork

(3) prove semi-conservative nature of DNA replication

(4) polymerize in the 5’-to-3’ direction and explain 3’-to-5’ DNA replication

The two polynucleotide chains in DNA are:

(1) parallel

(2) discontinuous

(3) antiparallel

(4) semiconservative

One gene-one enzyme relationship was established for the first time in:

(1) Neurospora crassa

(2) Salmonella typhimurium

(3) Escherichia coli

(4) Diplococcus pneumoniae

A sequential expression of a set of human genes occurs when a steroid molecule binds to the:

1. transfer RNA

2. messenger RNA

3. DNA sequence

4. ribosome

Which antibiotic inhibits interaction between t-RNA and m-RNA during bacterial protein synthesis?

(1) Erythromycin

(2) Penicillin

(3) Streptomycin

(4) Tetracycline

Amino acid sequence, in protein synthesis is decided by the sequence of

1. t-RNA

2. m-RNA

3. c-DNA

4. r-RNA