Thalassemia and sickle-cell anaemia are caused due to a problem in globin molecule synthesis. Select the correct statement.
1. Both are due to a qualitative defect in globin chain synthesis
2. Both are due to a quantitative defect globin chain synthesis
3. Thalassemia is due to less synthesis of globin molecules
4. Sickle-cells anaemia is due to a quantitative problem of globin molecules