| Statement I: | RNA interference takes place in all eukaryotic organisms as method of cellular defense. |
| Statement II: | RNAi involves the silencing of a specific mRNA due to a complementary single stranded RNA molecule that binds and prevents translation of mRNA |
| 1. | creating pores in the midgut |
| 2. | damaging the respiratory system |
| 3. | degenerating the nervous system |
| 4. | altering the pH of body fluids |
| List-I | List-II | ||
| A. | Genetically engineered Human Insulin | I. | Gene therapy |
| B. | GM Cotton | II. | E.Coli |
| C. | ADA Deficiency | III. | Antigen-antibody interaction |
| D. | ELISA | IV. | Bacillus thuringiensis |
| A. | The inactive toxin converted into active form due to alkaline pH of gut of insect |
| B. | Bacillus thuringiensis produce crystals with toxic insecticidal proteins. |
| C. | The alkaline pH solubilises the crystals. |
| D. | The activated toxin binds to the surface of midgut cells, creates pores and causes death of the insect. |
| E. | The toxin proteins exist as inactive protoxins in bacteria. |
| Statement I: | The Indian Government has set up GEAC, which will make decisions regarding the validity of GM research. |
| Statement II: | Biopiracy is the term used to refer to the use of bio-resources by native people |
| 1. | Bt toxin requires acidic pH for activation |
| 2. | Bacillus has protective mechanism against it |
| 3. | In Bacillus, it is present in an inactive state and once insects ingests it, it is converted to active form |
| 4. | The protoxin requires protein conjugate for its activation |
| Assertion (A): | Some ethical standards are required to evaluate the morality of scientific human activities that might help or harm living organisms. |
| Reason (R): | Genetic Engineering Approval Committee make decisions regarding the validity of Genetically Modified (GM) research and the safety of introducing GM organisms for public services. |
| 1. | Both (A) and (R) are True and (R) is the correct explanation of (A). |
| 2. | Both (A) and (R) are True but (R) is not the correct explanation of (A). |
| 3. | (A) is True but (R) is False. |
| 4. | (A) is False but (R) is True. |
| Statement I: | Two DNA sequences were prepared corresponding to A and B, chains of human insulin and were introduced in the plasmids of Agrobacterium to produce insulin chain. |
| Statement II: | Chain A and B were produced separately, extracted and combined by creating disulphide bonds to form human insulin. |
| List-I | List-II | ||
| A. | \(\alpha-1\) antitrypsin | I. | Cotton bollworm |
| B. | Cry IAb | II. | ADA deficiency |
| C. | Cry IAc | III. | Emphysema |
| D. | Enzyme replacement therapy | IV. | Corn borer |