In which disorder, change of single base pair in the gene for beta globin chain results in change of glutamic acid to valine?
1. Thalassemia 2. Sickle cell anemia
3. Haemophilia 4. Phenylketonuria
Subtopic:  Mendelian Disorders: Sickle Cell Anemia |
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 Select the correct statements about sickle cell anemia:
A: There is a change in the gene for beta-globin
B: In beta-globin, there is a valine in place of Lysine
C: It is an example of point mutation
D: In the normal gene, U is replaced by A

Choose the correct answer from the options given below:
1. (B), (C) and (D) only 2. (B) and (D) only
3. (A), (B) and (D) only 4. (A) and (C) only
Subtopic:  Mendelian Disorders: Sickle Cell Anemia |
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In a cross between a male and female, both heterozygous for sickle cell anaemia gene, what percentage of the progeny will be diseased?

1. 25% 2. 100%
3. 50% 4. 75%
Subtopic:  Mendelian Disorders: Sickle Cell Anemia |
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Select the correct match:

1. Phenylketonuria Autosomal dominant trait
2. Sickle cell anemia Autosomal recessive trait chromosome - 11
3. Thalassemia X linked
4. Haemophilia Y linked

Subtopic:  Mendelian Disorders: Sickle Cell Anemia |
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Pick out the correct statements:
I:  Haemophilia is a sex-linked recessive disease. 
II:  Down’s syndrome is due to aneuploidy. 
III:  Phenylketonuria is an autosomal recessive gene disorder. 
IV:  Sickle cell anaemia is an X-linked recessive gene disorder
1. II and IV are correct
2. I, III and IV are correct
3. I, II and III are correct
4. I and IV are correct
Subtopic:  Mendelian Disorders: Sickle Cell Anemia | Mendelian Disorders | Mendelian Disorders: Hemophilia | Non - Disjunction & Aneuploidy |
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Sickle cell anaemia is:

1. an autosomal linked dominant trait
2. caused by substitution of valine by glutamic acid
in the globin chain of haemoglobin
3. caused by a change in base pair of DNA
4. characterized by elongated sickle like RBCs with
a nucleus

Subtopic:  Mendelian Disorders: Sickle Cell Anemia |
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Sickle cell anaemia is due to:

1. Change of Amino Acid in α-chain of Haemoglobin.
2. Change of Amino Acid in β-chain of Haemoglobin.
3. Change of Amino acid in both α and β chains of Haemoglobin.
4. Change of Amino acid either α or β chain of Haemoglobin.

Subtopic:  Mendelian Disorders: Sickle Cell Anemia |
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