The length of DNA molecule greatly exceeds the dimensions of the nucleus in eukaryotic cells. How is this DNA accommodated?

(1) Deletion of non essential genes

(2) Super-coiling in nucleosomes

(3) DNAse digestion

(4) Through elimination of repetitive DNA

During transcription RNA polymerase holoenzyme binds to a gene promoter and assumes a saddle-like structure. What is it’s DNA-binding sequence?

(1) TTAA

(2) AATT

(3) CACC

(4) TATA

Differentiation of organs and tissues in a developing organism, is associated with:

(1) developmental mutations

(2) differential expression of genes

(3) lethal mutations

(4) deletion of gens

The Okazaki fragments in DNA chain growth:

(1) result in transcription

(2) polymerize in the 3’-to-5’ direction and forms replication fork

(3) prove semi-conservative nature of DNA replication

(4) polymerize in the 5’-to-3’ direction and explain 3’-to-5’ DNA replication

The two polynucleotide chains in DNA are:

(1) parallel

(2) discontinuous

(3) antiparallel

(4) semiconservative

One gene-one enzyme relationship was established for the first time in:

(1) Neurospora crassa

(2) Salmonella typhimurium

(3) Escherichia coli

(4) Diplococcus pneumoniae

A sequential expression of a set of human genes occurs when a steroid molecule binds to the:

1. transfer RNA

2. messenger RNA

3. DNA sequence

4. ribosome

Which antibiotic inhibits interaction between t-RNA and m-RNA during bacterial protein synthesis?

(1) Erythromycin

(2) Penicillin

(3) Streptomycin

(4) Tetracycline

Amino acid sequence, in protein synthesis is decided by the sequence of

(1) t-RNA

(2) m-RNA

(3) c-DNA

(4) r-RNA

One gene-one enzyme hypothesis was postulated by:

1. R. Franklin

2. Hershey and Chase

3. A. Garrod 

4. Beadle and Tatum